11beta hydroxysteroid dehydrogenase type 2

Lise Alschuler, ND , received her doctoral degree in naturopathic medicine from Bastyr University in 1994. She is board-certified in naturopathic oncology and has been a practicing naturopathic physician since 1994, currently with Naturopathic Specialists in Scottsdale, AZ. Dr Alschuler is past-president of the AANP and a founding board member of the Oncology Association of Naturopathic Physicians. She currently serves as a director on both the American Board of Naturopathic Oncology and the Naturopathic Post-Graduation Association. Previously, she served as department head of Naturopathic Medicine at Midwestern Regional Medical Center – Cancer Treatment Centers of America, was the clinic medical director and Botanical Medicine chair at Bastyr University Natural Health Clinic, and also a faculty member at SCNM. Dr Alschuler is the co-author of The Definitive Guide to Cancer: An Integrative Approach to Prevention, Treatment and Healing , also Five To Thrive: Your Cutting-Edge Cancer Prevention Plan . She co-created , a website dedicated to providing information about integrative cancer prevention and treatment, and she co-hosts a radio show, Five To Thrive Live! on about living healthier lives in the face of cancer.

Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and hence may explain why aspirin improves glycemic control in type 2 diabetes. [8] Epigallocatechin gallate from green tea can also potently inhibit this enzyme, [9] green tea is a complex mixture of various phenolics with contents varying with production and processing, some of the phenolics are known HDAC inhibitors that alter genetic expression. EGCG as usually consumed in green tea is poorly absorbed into the bloodstream, more research is needed to reach firm conclusions.

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This gene encodes a member of the aldo/keto reductase superfamily , which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [7]

11beta hydroxysteroid dehydrogenase type 2

11beta hydroxysteroid dehydrogenase type 2

This gene encodes a member of the aldo/keto reductase superfamily , which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [7]

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