2aerosolized steroids

A new drug for RSV, ALN-RSV01, is currently being evaluated in a Phase 2 multi-center clinical trial.  The results of a small clinical trial using ALN-RSV01 in lung transplant recipients infected with RSV were recently published.  The drug reduced symptom scores, and more importantly, reduced the incidence of BOS 90 days after the infection.  The Phase 2 clinical trial aims to corroborate those findings in a larger cohort and is planning to enroll patients this season.  Obviously, this would be an important breakthrough in the management of the acute infection and the long-term sequelae in lung transplant recipients.

“When you turn on the jets, this bacteria becomes aerosolized, and you inhale it,” Rose explains. Once it reaches your lungs, the bacteria can cause symptoms like fever andshortness of breath. If you continue to use your tub, the inflammation persists and worsens, and can cause lasting fatigue, weight loss and other more serious side effects. “A lot of doctors don’t ask if a person with these symptoms has been using a hot tub, and people become very sick,” Rose says. “If you keep using your tub, taking antibiotics or steroids won’t do any good.”

Zab Mosenifar, MD, FACP, FCCP  Geri and Richard Brawerman Chair in Pulmonary and Critical Care Medicine, Professor and Executive Vice Chairman, Department of Medicine, Medical Director, Women's Guild Lung Institute, Cedars Sinai Medical Center, University of California, Los Angeles, David Geffen School of Medicine

Zab Mosenifar, MD, FACP, FCCP is a member of the following medical societies: American College of Chest Physicians , American College of Physicians , American Federation for Medical Research , American Thoracic Society

Disclosure: Nothing to disclose.

Tracheoesophageal fistula is a devastating but rare complication of endotracheal intubation. It should be suspected in intubated patients with recurrent pneumonias. Adding methylene blue to the enteral feed and finding it in the endotracheal aspirate supports the diagnosis, however, does not confirm it. This should be followed with a barium swallow, esophagoscopy or bronchoscopy. The fistula needs to be repaired surgically which may not be feasible in the critically ill. Until it is, conservative management involves frequent suctioning, elevation of the head end of the bed and advancing the ET tube distal to the opening of the fistula.

The varicella zoster immune globulin product licensed for use in the United States is VariZIG™. VariZIG should be given as soon as possible after exposure to varicella-zoster virus (VZV) and within 10 days of exposure. For more information, see the Morbidity and Mortality Weekly Report article on Updated Recommendations for Use of VariZIG — United States, 2013 . VariZIG is currently available from 2 distributors in the US. See the Morbidity and Mortality Weekly Report announcement on the Expansion of VariZIG distribution in the United States.

2aerosolized steroids

2 aerosolized steroids

Tracheoesophageal fistula is a devastating but rare complication of endotracheal intubation. It should be suspected in intubated patients with recurrent pneumonias. Adding methylene blue to the enteral feed and finding it in the endotracheal aspirate supports the diagnosis, however, does not confirm it. This should be followed with a barium swallow, esophagoscopy or bronchoscopy. The fistula needs to be repaired surgically which may not be feasible in the critically ill. Until it is, conservative management involves frequent suctioning, elevation of the head end of the bed and advancing the ET tube distal to the opening of the fistula.

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