Of course, Arimidex is often used by steroid users to decrease over-aromatization from driving their testosterone into supraphysiological zones, . way above normal, which in turn leads to elevated estradiol. They aslo use it post-cycle period when they are desperately trying to get their testosterone jumpstarted - sometimes unsucccessfully I might add. As strange and annoying as this is, steroid users and fertility doctors were some of the early pioneers of Armidex usage.
Evidence of fetotoxicity, including delayed fetal development (., incomplete ossification and depressed fetal body weights), was observed in rats administered doses of 1 mg/kg/day (which produced plasma anastrozole C ssmax and AUC 0-24 hr that were 19 times and 9 times higher than the respective values found in postmenopausal volunteers at the recommended dose). There was no evidence of teratogenicity in rats administered doses up to mg/kg/day. In rabbits, anastrozole caused pregnancy failure at doses equal to or greater than mg/kg/day (about 16 times the recommended human dose on a mg/m 2 basis); there was no evidence of teratogenicity in rabbits administered mg/kg/day (about 3 times the recommended human dose on a mg/m 2 basis).
UPDATE 6/14/2017: Since writing this post I no longer use Arimidex. It’s simply far too easy to tank your E2 levels. Arimidex does not work like Tylenol. (Meaning it doesn’t work within hours. Instead it can take days for your E2 levels to drop. Additionally, you may inadvertently cause your E2 levels to “tank”. You may attempt to raise them by giving yourself a higher dose of Testosterone. But this is ultimately a yo yo recipe for disaster. So what’s the best way to manage your E2 levels? Splitting my dosage . I’d read about this many times online but really didn’t want to deal with the hassle of two shots every week. Hindsight is 20/20, it’s the best decision I ever made. I generally no longer have E2 troubles. My energy levels are back to normal, my weight is under control (down almost 30 pounds with exercise!) and my sexual performance is relatively normal.