AB - A metabolic imbalance between anabolic drive and catabolic forces is commonly observed in chronic heart failure (CHF) patients, with the latter prevailing over anabolic hormones. Moreover, anabolic deficiencies are independent markers of poor prognosis. This finding represents a solid background for the implementation of therapeutic trials based on replacement therapy. The somatotropic axis (GH/IGF-1) is the most powerful anabolic axis of the body and its decline is related with a poor outcome and a worse clinical status. Growth hormone (GH) administration may enter the therapeutic arena as adjunctive treatment in patients affected by CHF and GH/IGF-1 deficiency. The . project aims at investigating the relationship between CHF and hormonal deficiency.
The next study we’re going to look at is how BCAA supplementation help preserves muscle in times of weight loss or muscle wasting conditions or diseases. This study looked at BCAA supplementation in patients with liver cirrhosis . Dr. Willis Maddrey looked at how BCAA supplementation effected nitrogen retention of those with severe liver disease . The group was split into two, one half were given an intravenous (IV) solution at night enriched with BCAAs and the other half, the control group, placebo. Nitrogen balance improved in those supplementing BCAAs compared to the control, which translates to muscle being spared overnight and not used for energy. Again, the BCAAs were shown to be anti-catabolic in this instance.