On the other hand, there are instances which show the problems with improved and advanced technology or the solution for one problem with the help of technology is giving rise to another problem. Instead of taking care personally we are sending sms or giving a call on important occasions which were attended personally in olden days. With the use of same internet children are getting addicted to online games and their physical activities and exercises are becoming considerably less. The same social networks are creating rivalry between best friends and couples are getting divorced. The same aviation technology is giving health problems for their workers and creating serious environmental threats. With the heavy usage of fertilizers soil is losing its natural fertility and several varieties of plants became extinct.
The ( R )-(−)- enantiomer of modafinil, known as armodafinil , was also subsequently found to act as a D 2 High receptor partial agonist , with a K i of 16 nM, an intrinsic activity of 48%, and an EC 50 of 120 nM, in rat striatal tissue.  The ( S )-enantiomer is inactive with respect to the D 2 receptor.  Modafinil has been found to directly inhibit the firing of midbrain dopaminergic neurons in the ventral tegmental area and substantia nigra of rats via activation of D 2 receptors.