Non steroidal anti inflammatory agents and xerostomia

NSAIDs have anti-inflammatory (reduce inflammation), analgesic (relieve pain) and antipyretic (lower temperature) effects. Although different NSAIDs have different structures, they all work by blocking cyclooxygenase (COX) enzymes. There are two main types of COX enzymes: COX-1 and COX-2. Both types produce prostaglandins; however, the main function of COX-1 enzymes is to produce baseline levels of prostaglandins that activate platelets and protect the lining of the gastrointestinal tract, whereas COX-2 enzymes are responsible for releasing prostaglandins after infection or injury. Prostaglandins have a number of different effects, one of which is to regulate inflammation. Most NSAIDs inhibit both enzymes, although a few are available that mainly inhibit COX-2. The pain-relieving and anti-inflammatory effects of NSAIDs are mainly due to inhibition of COX-2, and their unwanted side effects are largely due to inhibition of COX-1.

Risks associated with NSAIDs are detailed on the package inserts and Client Information Sheets that accompany all veterinary NSAIDS dispensed to clients. A Client Information Sheet should always be given to the client with each NSAID prescription. Pet owners should read this information carefully. Owners and veterinarians should carefully consider the potential benefits and risks of using an NSAID and other treatment options before deciding to use an NSAID. Use the lowest effective dose for the shortest duration consistent with individual response.

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  • Citation tools Download this article to citation manager Arfè Andrea , Scotti Lorenza , Varas-Lorenzo Cristina , Nicotra Federica , Zambon Antonella , Kollhorst Bianca et al. Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case-control study BMJ 2016; 354 :i4857
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    NSAIDs increase the risk of potentially fatal, stomach and intestinal adverse reactions (for example, bleeding, ulcers, and perforation of the stomach or intestines ). These events can occur at any time during treatment and without warning symptoms. Elderly patients are at greater risk for these adverse events. NSAIDs (except low dose aspirin) may increase the risk of potentially fatal heart attacks , stroke , and related conditions. This risk may increase with duration of use and in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft ( CABG ) surgery.

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    Non steroidal anti inflammatory agents and xerostomia

    non steroidal anti inflammatory agents and xerostomia

    NSAIDs increase the risk of potentially fatal, stomach and intestinal adverse reactions (for example, bleeding, ulcers, and perforation of the stomach or intestines ). These events can occur at any time during treatment and without warning symptoms. Elderly patients are at greater risk for these adverse events. NSAIDs (except low dose aspirin) may increase the risk of potentially fatal heart attacks , stroke , and related conditions. This risk may increase with duration of use and in patients who have underlying risk factors for heart and blood vessel disease. Therefore, NSAIDs should not be used for the treatment of pain resulting from coronary artery bypass graft ( CABG ) surgery.

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