Nongenomic actions of steroid hormones in reproductive tissues

Calcium metabolism appears to underlie neuronal cell death via excitotoxicity, [103] [104] [105] [106] and hormonally active vitamin D confers a protective effect in vitro at physiologically relevant concentrations up to 100nM but not above. [107] This mechanism of protection appears to be mediated via a downregulation of L-type voltage-sensitive Ca 2+ ion channels, [107] an effect which has also been seen in bone cells. [108] [109] These L-type channels have been implicated in excitotoxicity. [110] [111]

Nongenomic actions of steroid hormones in reproductive tissues

nongenomic actions of steroid hormones in reproductive tissues

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