There is limited information available on the pharmacokinetics of oxymetholone.  It appears to be well-absorbed with oral administration .  Oxymetholone has very low affinity for human serum sex hormone-binding globulin (SHBG), less than 5% of that of testosterone and less than 1% of that of DHT.  The drug is metabolized in the liver by oxidation at the C2 position, reduction at the C3 position, hydroxylation at the C17 position, and conjugation .   The C2 hydroxymethylene group of oxymetholone can be cleaved to form mestanolone (17α-methyl-DHT), which may contribute to the effects of oxymetholone.  The elimination half-life of oxymetholone is unknown.  Oxymetholone and its metabolites are eliminated in the urine .  
i realize that ur post is from 2 months ago, but in case you were still wondering... i started off with 25mg two times for the first week. My appetite was aggressive. you know that intense feeling when your large intestines are full and you have to get to a toilet fast while your fighting to hold the waste in.. well, the appetite is emotionally similar, i wanted to eat really bad and i didnt care if it was mc'd's .. however i am disciplined and so i didnt eat the shit, but the attitude of "i dont care what it is, i will eat it!!," was def. there. For week 2 and currently, ive been dosing with 50mgs two times daily. I no longer have the same intense urge to get to a meal fast. i still put down some food, no doubt, but that feeling in the gut for food is not there. it was gone on day one of the 50mgs two times daily. i havent noticed any dif. in size progression with the upped dose, its still progressing at the same rate if not a little more with the increased dose, but i think there could be something to do with the difference i feel with the 50 two times daily vs the 25 two times daily. its something to look into. well that is my experience with this thus far. love it.
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