Occasionally, tapering on an every other day basis may be useful. For example, instead of tapering from 4 milligrams to 3 milligrams of prednisone, a doctor may prescribe taking 4 milligrams one day and 3 milligrams the next day for one week (., an alternate day taper). Then, if successful, the doctor may prescribe 4 milligrams one day and 2 milligrams the next and so on until on only 4 milligrams every other day (., 4 milligrams one day and zero the next day). The doctor continues to try to decrease the dose on that alternate day.
processing.... Drugs & Diseases prednisone (Rx) Brand and Other Names: Deltasone, Rayos, more... Prednisone Intensol, Sterapred, Sterapred DS
During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every 6 hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenocortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, Prednisone, and prednisolone, are considered to be short acting (producing adrenocortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.